GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs1499614 | 1 | rs2141924 | chr7:66186246 | CCT6P1 | chr7:65216092-65228661:+ | 0.36 | 4.78 | 2.52E-6 | Gout |
| BLCA | cis | rs2143950 | 1 | rs2143950 | chr14:35572357 | PPP2R3C | chr14:35554679-35591679:- | 0.29 | 4.56 | 6.9E-6 | Atopic dermatitis |
| BLCA | cis | rs2985684 | 1 | rs2147712 | chr14:50091684 | RPL36AL | chr14:50085407-50087349:- | 0.24 | 4.36 | 1.67E-5 | Carotid intima media thickness |
| BLCA | cis | rs9457247 | 1 | rs2149085 | chr6:167371110 | RNASET2 | chr6:167343008-167412795:- | 0.23 | 4.72 | 3.36E-6 | Crohn's disease |
| BLCA | cis | rs9457247 | 1 | rs2149090 | chr6:167372764 | RNASET2 | chr6:167343008-167412795:- | 0.22 | 4.71 | 3.4E-6 | Crohn's disease |
| BLCA | cis | rs9457247 | 1 | rs2149091 | chr6:167372786 | RNASET2 | chr6:167343008-167412795:- | 0.22 | 4.71 | 3.4E-6 | Crohn's disease |
| BLCA | cis | rs2149423 | 1 | rs2149423 | chr13:36772381 | SOHLH2 | chr13:36742347-36871992:- | 0.27 | 4.53 | 7.72E-6 | Glucose homeostasis traits |
| BLCA | cis | rs56322409 | 1 | rs2152916 | chr10:97392265 | ENTPD1 | chr10:97471536-97637022:+ | 0.19 | 4.86 | 1.73E-6 | Blood metabolite levels |
| BLCA | cis | rs1003719 | 1 | rs2154536 | chr21:38492147 | PIGP | chr21:38437664-38445458:- | -0.3 | -5.3 | 1.95E-7 | Eye color traits |
| BLCA | cis | rs1003719 | 1 | rs2154536 | chr21:38492147 | TTC3 | chr21:38445571-38575406:+ | 0.25 | 5.14 | 4.38E-7 | Eye color traits |
| BLCA | cis | rs7112513 | 1 | rs2155583 | chr11:116915217 | PCSK7 | chr11:117075789-117102811:- | -0.39 | -5.05 | 6.74E-7 | Protein quantitative trait loci |
| BLCA | cis | rs216345 | 1 | rs216345 | chr9:33799370 | NUDT2 | chr9:34329504-34343695:+ | -0.24 | -4.9 | 1.4E-6 | Bipolar disorder |
| BLCA | cis | rs798766 | 1 | rs2166580 | chr4:1743169 | FAM53A | chr4:1641609-1685854:- | -0.31 | -4.45 | 1.11E-5 | Urinary bladder cancer;Bladder cancer |
| BLCA | cis | rs1577917 | 1 | rs2166663 | chr6:86593896 | SNHG5 | chr6:86386726-86388451:- | -0.56 | -10.22 | 7.62E-22 | Response to antipsychotic treatment |
| BLCA | cis | rs4372836 | 1 | rs2169748 | chr2:28957753 | TRMT61B | chr2:29072690-29093175:- | 0.3 | 5.26 | 2.46E-7 | Body mass index |